THE ALTERATION OF AFP mRNA CONCENTRATION IN PERIPHERAL BLOOD WITH HEPATOCELLULAR CARCINOMA DURING TRANSHEPATIC ARTERAL CHEMOTHERAPY AND EMBOLIZATION / 解放军医学杂志

ABSTRACT

To find the rule of alterations in AFP mRNA concentration in peripheral blood in patients with hepatocellular carcinoma(HCC) before and after the treatment with transhepatic arterial chemotherapy and embolization(TAE), 15 cases of the pateints with HCC were included in this survey. The AFP mRNA concentration in peripheral blood of the patients were investigated using compatitive RT PCR technique before and 1,2,3,4, 5,6,7, 14, 28 days after TAE. The results showed that AFP mRNA concentration on the third day after TAE was the highest. It declined to the level before treatment during one week.It suggested that AFP mRNA concentration changed with a rule, and following the rule, preventive measure to distant metastasis could be instituted in clinical work.