STUDY ON THE EXPRESSION OF ICAM-1 AND TNF-? IN GASTRIC MUCOSAL CELL DURING DRUG INDUCED GASTRIC MUCOSAL INJURY IN RAT / 解放军医学杂志
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-551969
Responsible library:
WPRO
ABSTRACT
To investigate the expression of ICAM 1 and TNF ? in gastric mucosal cell during drug induced mucosal injury, the authors carried out the study in SD rats with aspirin by mouth with immunohistochemical method . The results showed that ICAM 1 began to express at 30min after administration of aspirin, peaked at 1h, maintained until 6h, decreased at 12h,and expressed slightly at 24h . TNF ? began to express at 15min, peaked at 3h to 6h,decreased at 12h, and expressed significantly at 24h. There was a slight ICAM 1 and TNF ? expression in gastric mucosal cells in the control group. It was suggested that the expression of ICAM 1 and TNF ? plays an important role in the mechanisms of gastric mucosal injury .
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Medical Journal of Chinese People's Liberation Army
Year:
1983
Document type:
Article