Humoral immune response to gene vaccine against adr hepatitis B virus / 第二军医大学学报
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-552227
Responsible library:
WPRO
ABSTRACT
Objective:
To construct HBV adr gene vaccine pCMVS 2-S and to observe the specific humoral immune responses in C57BL/6 mice after gene immunization.Methods:
The HBV gene vaccine was injected into tibialis anterior muscles of C57BL/6 mice. ELISA was used to detected the anti-HBs antibody in mice sera at various time points after gene transfer.Results:
Anti-HBs in sera of mice was tested positive 1 week after plasmid injected, the level of antibody peaked 4 weeks later, and kept high titer for at least 2 months.Conclusion:
The good response of humoral immunity can be induced by injection of pCMVS 2-S in C57BL/6 mice.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Document type:
Article