Influence of thyroid function on metabolisms of diazepam and nordiazepa m in rats / 中国临床药理学与治疗学

ABSTRACT

AIM: To observe the influence of thyroid function on metabol is m of diazepam and nordiazepam in rats. METHODS: HPLC method was used to determine the blood concentrations of diazepam and nordiazepam from rats with different thyroid function. RESULTS: Diazepam was metaboli zed rapidly in the rats with hyperthyroidism, the Cmax and AUC were decreased, a nd the T 1/2 was cut short, but it showed an opposite resul ts in the rats with hypothyroidism. While pharmacokinetic parameters of diazepam were opposite in comparison with nordiazepam. CONCLUSION: Metab olism of diazepam increases in rats with hyperthyroidism.