Expression of vascular endothelial growth factor in chronic hypoxia and hypercapnia rats and effects of SHENYI Capsule / 中国临床药理学与治疗学
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-555112
Responsible library:
WPRO
ABSTRACT
AIM:
To explore the roles of vascular endothelial growth factor (VEGF) in hypoxia pulmonary hypertension and effects of SHENYI Capsule.METHODS:
Thirty SD rats were randomly divided into normal control group (N), hypoxia hypercapnia group (F), and hypoxia hypercapnia+SHENYI Capsule group (S). The levels of VEGF in serum and lung tissue are measured by ELISA, the ultrastructure of pulmonary arterioles was observed by electron microscopy, and the expression of VEGFmRNA was observed by in situ hybirdization.RESULTS:
Mean pulmonary arterial pressure (mPAP), weight ratio of RV to LV+S, the levels of VEGF in serum, and lung tissue of group F were significantly higher than those of group N and group S (P
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2002
Document type:
Article