Advances in experiment of nitric oxide and cerebral ischemia / 中国药理学通报

ABSTRACT

Many studies have showed that nitric oxide(NO) might in duce dual effects during focal cerebral ischemic injury,namely neuroprotctive and neurotoxic effects.After cerebral ischemia, NO induced by endothelial NO synthase(eNOS) has neuroprotective effect. NO induced by neuronal NO synthase(nNOS) and inducible NO synthase(iNOS) has neurotoxic effect. Dual effects of nitric oxide have been becoming novel subjects for the protection of focal cerebral ischemic injury.