EFFECTS OF DIFFERENT DIETARY FATTY ACID COMPOSITION ON T LYMPHOCYTE FUNCTIONS AND LIPID PEROXIDATION IN MICE / 营养学报

ABSTRACT

Objective: To study the effects of dietary n-6/n-3 PUFA ratio on T lymphocyte functions in mice. Methods: 96 male BALb/c mice were randomly divided into 8 groups with dietary SMP 11.53.7 or 11.51, respectively. The n-6/n-3 PUFA ratio was 1, 7.5, 15, 30 respectively in each SMP diet. Each diet contained 70.0g/kg lipid,and different n-6/n-3 PUFA ratios by mixing different oils. At the end of 12w, all mice were killed and blood was collected. The spleen T lymphocyte proliferation, IL-2 production and serum MDA were measured. Results: When dietary SMP was 11.53.7, the proliferation of spleen lymphocytes and IL-2 production from mice with dietary n-6/n-3 ratio 1 were suppressed (P