Effects of naoyikang on capability of learning and memory in Alzheimer’s disease model mice / 中国临床药理学与治疗学
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-555968
Responsible library:
WPRO
ABSTRACT
AIM:
To observe the effects of naoyikang on the capability of learning and memory in Alzheimer’s disease model mice.METHODS:
The mice model was established by intraperitoneal injection of D BZ Gal and NaNO 2, the capability of learning and memory was tested on mice by electrical maze and water maze, the levels of superoxide dismutase (SOD) and malondialdehyde(MDA) of brain tissues were assayed by biochemical methods,and the changes in ultrastructure were observed by Transmission Electron Microscope.RESULTS:
The capability of learning and memory of model mice decreased and the level of SOD of model mice decreased and MDA increased. Compared with the madel group, they were obviously improved in low, middle and high doses ( 2.4 , 7.2 , 24 g?kg -1 ?d -1 ) of naoyikang group ([WTBX P
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2000
Document type:
Article