Transdermal characteristics of methylphenidate hydrochloride / 第二军医大学学报
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-556106
Responsible library:
WPRO
ABSTRACT
Objective:
To investigatethe transdermal delivery characteristics of methylphenidate hydrochloride (MPH) in vitro.Methods:
Characteristics of MPH crossing nude rats skin were studied with Franz diffusion cells. A high performance liquid chromatographic (HPLC) method was established to determine the concentration of MPH crossed the skin. The permeability coefficient (P), steady state flux (J) and lag time(LT) for MPH through the skin of nude rats treated with various enhancers were compared with those of control.Results:
The permeability coefficient increased with the increase of MPH concentration. The penetration of MPH through nude rats skin was obviously enhanced by 8%Azone and 5%propylene glycol (P
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
1982
Document type:
Article