The effect of bisoprolol on action potential duration (APD) and K~+ current in ventricular myocytes after myocardial infarction / 解放军医学杂志
Article
in Zh
| WPRIM
| ID: wpr-556502
Responsible library:
WPRO
ABSTRACT
Objective To investigate the changes of action potential duration (APD) and transient outward K + current (I to) and inward rectifier K + current(I K1) of ventricular myocytes after 3 weeks of myocardial infarction, and to inquire into the effect of bisoprolol. Methods APD was recorded with microelectrode. Ventricular myocytes were singly isolated from rabbit heart using modified Langendoff perfusion and soaked with collagenase. I to and I K1 of single rabbit ventricular myocytes were recorded by whole-cell path-clamp technique. Results Both APD 50 and APD 90 of the cell from noninfarcted region in MI group were markedly longer than that in sham group (P
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Medical Journal of Chinese People's Liberation Army
Year:
1983
Document type:
Article