Protective effects of curcumin on myocardial ischemia reperfusion injury in rats / 中国药理学通报

ABSTRACT

Aim To study the protective effects of curcumin on myocardial reperfusion injury in rats.Methods Myocardial ischemia reperfusion injury model was established through occluding the left anterior descending branch of coronary artery for 60 min and removing the ligation later to reperfuse for 30 min in vivo.Different doses of curcumin were administered through intravenous injection 5 min before the onset of ischemia.The changes of hemodynamics were recorded and myocardial infarct sizes were measured.Results Curcumin(20,40 mg?kg~(-1))improved the hemodynamics during myocardial ischemia reperfusion in a dose-dependent manner,as shown by the significant increase in LVSP and?dp/dt_(max) and the decrease in LVEP.Moreover,curcumin reduced the myocardial infarct sizes.Conclusion Curcumin exerts protective effects on myocardial ischemia reperfusion injury.