Curcumin causes histone acetylation enhancement in Raji,HL-60 and K562 cell lines / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
in Zh
| WPRIM
| ID: wpr-558160
Responsible library:
WPRO
ABSTRACT
Aim To investigate whether the mechanism of curcumin antagonizing tumor correlates with histone acetylation/deacetylation,which is regarded as modulation of transcription level.Methods Measure the survival rates of Raji by treatment with various concentration of curcumin or TSA by the method of MTT;Measure the expression of acetylated histone_3 in Raji,HL60 and K562 when treated with various concenration of curcumin or TSA by means of Immunohistochemistry and FACS.Results Curcumin could inhibit Raji cell proliferation in a time-dependent and dose-dependent manner.Curcumin at the concertration of 25 ?mol?L~(-1) could enhance acetylated histones in the three tumor cells(P
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Document type:
Article