Long term effect of exendin-4 on body weight reduction in rats / 肠外与肠内营养

ABSTRACT

Objective:To study the effect of exendin-4 on weight reduction in normal rats after long-term subcutaneous injection.Methods:40 Wistar rats aged 6-8 weeks were randomly divided into four groups and were injected subcutaneously with 0,1,5,25 ?g/kg exendin-4 for 26 weeks.Body weight,food intake,cholesterol,triglyceride,kidney fat pad weight and diameter of adipocytes were measured.Results:Body weight,kidney fat pad weight and serum tricyleride in 25?g/kg group were significantly lower than that in control group(P