Helicobacter pylori genotypes of gastrointestinal B cell lymphoma / 北京大学学报(医学版)
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-558637
Responsible library:
WPRO
ABSTRACT
Objective:
To assess the expression of specific virulence-associated Helicobacter pylori (Hp) genotypes, (cag A, vac A, and ice A status) in primary gastrointestinal B cell lymphoma.Methods:
Forty-nine paraffin wax embedded tissues were analyzed by immunohistochemical staining and poly-merase chain reaction.Results:
There were 14 cases of mucosa associated lymphoid tissue lymphoma ( MALT-L) (8 in stomach, and 6 in intestine) and 35 cases of diffuse large B cell lymphoma (DLBCL) (21 in stomach, and 14 in intestine) in all. The positive rates of vac A s1 ,vac A s2 ,vac A m2,ice A 1 and cag A were 50. 0% ,42. 9% ,50. 0% , 14. 3% and 85. 7% in MALT-L; 57. 1% ,40. 0% ,25. 7% , 5.7% and91.4% in DLBCL, respectively.Conclusion:
High toxicity cag A + Hp strains.seem to play a role in the pathogenesis of gastrointestinal B cell lymphoma, whereas vac A m2 may be more associated with MALT-L. Clinical stage was not associated with virulence-associated Hp genotypes.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Peking University(Health Sciences)
Year:
2004
Document type:
Article