Effects of soy oligosaccharides and peptides on blood lipid metabolism of rats / 第三军医大学学报

ABSTRACT

Objective To investigate the effects of soy oligosaccharides and peptides on lipid levels in rat plasma.Methods Sixty healthy SD rats were randomly divided into five groups fed respectively with normal diet(ND group),high-fatty diet(HFD group),HF diet+2% soy oligosaccharides(SO group),HF diet + 3% soy peptides(SP group),HF diet+2% soy oligosaccharides+3% peptides(SOP group) for 8 weeks,and the concentrations of blood lipid and apolipoprotein were measured at 28 d and 56 d.Results As compared with HFD group,the serum levels of total cholesterol(TC),triglycerol(TG),very low density lipoprotein cholesterol(VLDL-C) and low density lipoprotein cholesterol(LDL-C) and atherosclerosis index(AI) in SO,SP and SOP groups decreased significantly,while high density lipoprotein cholesterol(HDL-C) increased significantly;the level of plasma apolipoprotein A-Ⅰ(apoA-Ⅰ) increased significantly,while apolipoprotein B(apoB) and apoB/apoA-Ⅰ ratio decreased significantly,especially in SOP group.Conclusion Soy oligosaccharides and peptides can prevent hyperlipidemia by adjusting blood lipid metabolism in vivo effectively,especially when they are combined.