THE PREVENTIVE EFFECT OF LYCOPENE ON HYPERGLYCEMIA IN ALLOXAN-INDUCED DIABETIC RATS AND ITS MECHANISM / 营养学报
Acta Nutrimenta Sinica
; (6)1956.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-559305
Responsible library:
WPRO
ABSTRACT
Objective:
To study the preventive effect of lycopene (LP) on hyperglycemia in alloxan-induced diabetic rats, and reveal its possible mechanism.Method:
Forty Sprague-Dawley rats were randomized into 5 groupsthree groups of LP at doses of 5, 20, 50 mg(/kg bw ?d)for 15d, one control group and one model group of salad oil. Then alloxan (ALx) were injected intraperitoneally to the rats at dose of 150 mg/kg bw. At D4 and D14 after ALx injection, an oral glucose tolerance test (OGTT) was performed and body weight was measured, and at D14 GSP, FINS, NEFA, SOD,GSH-Px and MDA in liver were also determined .Results:
Compared with the indices in group with ALX injection only,both the 2h blood glucose and GSP in group with medium-dose LP decreased significantly(P
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Acta Nutrimenta Sinica
Year:
1956
Document type:
Article