Toxicological assessment on safety of Fangyouling, a cercaricide of preparation / 中国血吸虫病防治杂志

ABSTRACT

Objective To evaluate the safety of Fangyouling, a cercaricide of preparation. Methods All of the tests including the acute oral and dermal toxicity, acute eye and skin irritability and the dermal sensitivity reaction were carried out according to the toxicological test methods of pesticides for registration (GB 15670-1995). Results Fangyouling belonged to slight grade of acute toxicity through both oral and skin tests in rats. Fangyouling was not acute irritant for the skin and eyes in rabbits and weak allergic for the skin in guinea pigs. Conclusion Fangyouling may be a safe ceraricide preparation for prevention of Schistosoma japonicum cercariae infection by skin administration.