Animal Experimental Study between the EDRF/NO And Endothelin in Regulative Relations / 医学研究杂志
Journal of Medical Research
; (12)2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-561083
Responsible library:
WPRO
ABSTRACT
Objective To probe into modulation effect between the EDRF/NO And ET.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic change of MABP,plasm ET-ir and cGMP level of tissue is observed.Results Whole Wister rat's experiment results:
① In ET group,MABP first instantly(1~2min)reduces 6.58?0.67kPa,afterwards duratively enhances,it assumes the bidirectional response,when it reaches to 30min,MABP elevates 33.3?0.4kPa than before taking ET;Causes the aortic cGMP content to elevate,comparatively group control to increase 74.5%;② In L-NNA group,MABP slow rise,within 30min elevates to 4.62?2.04kPa;With control group comparison,the GMP level is reduced 5 times(0.42?0.08 versus the control 2.14?0.18pmol/mg Pr,P0.05);④ In Ach group,The vascular ET release reduces [406?31 versus control group 514?50pg/(g.w.w),P
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Medical Research
Year:
2006
Document type:
Article