Effect of the total saponins of Rubus parvifolius on the intracellular free calcium in ischemic hippocampal neurons / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-561872
Responsible library:
WPRO
ABSTRACT
Aim To study the effect of the total saponins of Rubus parvifolius(TSRP)on the intracellular free calcium levels in ischemic hippocampus neurons.Methods The cytosolic free calcium concentration in ischemic hippocampal neurons was measured by using Ca2+-sensitive fluorescent probe fluo-2/AM with a laser scanning confocal microscope.Results Application of TSRP inhibited free intracellular calcium in ischemic hippocampus neurons in a concentration-dependent manner.Conclusions These results suggest that TSRP might protect hippocampus neurons via attenuating calcium overload induced by ischemia.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Document type:
Article