Effects of a novel thiazolidinedione ANY_2 on glycometabolism in HepG_2 cells / 中国临床药理学与治疗学
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-563394
Responsible library:
WPRO
ABSTRACT
AIM:
To investigate the effects of a novel thiazolidinedione ANY2 on glycometabolism in HepG2 cells.METHODS:
HepG2 cells are exposed to high concentrations of insulin for 24 h to build the model of insulin-resistance(IR-HepG2).The effects of ANY2,including glucose consumption(GC),gluconeogenesis and glucolysis were tested in this model.RESULTS:
ANY2 could dose-dependently enhance GC in IR-HepG2 cells at high,medium and low levels of glucose.Compared with Modle Group,ANY2 increased IR-HepG2 cells glycogen synthesis significantly only in high dose group.It inhibited gluconeogenesis from lactic acid,but increased the production of lactic acid and the activity of pyruvate kinase(PK)in glucolysis.CONCLUSION:
Compound ANY2 has remarkable effects on improving glycometabolism in IR-HepG2 cells.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
1999
Document type:
Article