Electroacupuncture treats rat non-alcoholic fatty liver by blocking insulin resistance and peroxidation / 第三军医大学学报

ABSTRACT

Objective To investigate the mechanism of electroacupuncture in the treatment of non-alcoholic fatty liver disease(NAFLD).Methods Thirty-three male SD rats were randomized into 2 groupsnormal control group(n=11,fed with normal food)and experimental rats(n=23,fed with high-fat food).Eight weeks later,3 rats were randomly selected from the 2 groups respectively and killed to undergo pathological examination of the liver.When the establishment of experimental rats was confirmed,the remaining 20 experimental rats were divided into 2 equal subgroupsNAFLD group(fed continuously with high-fat food)and electroacupuncture treatment group(fed continuously with high-fat food and received the treatment 15 min per day,once a day for 4 weeks).Then all rats were killed to detect the serum levels of fasting blood glucose(FBG),fasting insulin(FINS)and free fatty acids(FFA),liver contents of malondialdehyde(MDA),glycerin tripalmitate(TG)and total cholesterol(TC),and the activities of liver superoxide dismutase(SOD)and glutathione(GSH).Liver pathological changes was examined.Results Compared with NAFLD group,electroacupuncture reduced the serum levels of FBG,FINS and FFA(P