TNF-α Expression in the Peritoneum of Curcumine Pretreated Acute Peritonitis Rat / 中国医科大学学报

ABSTRACT

Objective To investigate the effects of curcumine treatment on the expression of TNF-α in the peritoneum of acute peritonitis rats. Methods The rats were intrapertoneally injected Staphylococcus epidemidis (S.epidermidis) for the mixlelization of acute peritonitis. After a survival time of 3,6,12,24 and 48 hours,TNF-α expression in the peritoneum was detected by Western blot and RT-PCR in the rats of curcumin treatment group and non-curcumin treatment group. Results TNF-a expression showed time-dependent increase at 6,12,24 hours after the infection in the non-curcumin treatment group. In curcumin treatment group,TNF-α expression decreased at 6,12,24 hours after infection compared to non-curcumin treatment group. Conclusion Curcumin may be a protective agent in acute peri-tonitis induced by S.epidermidis.