Protective effects of crocetin on cerebral ischemia-reperfusion injury in mice / 中国临床药理学与治疗学
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-565458
Responsible library:
WPRO
ABSTRACT
AIM:
To research the protective effects of crocetin on cerebral ischemia-reperfusion(CIR) injury in mice.METHODS:
The effects of crocetin on brain edema,brain capillary permeability,the activities of lactate dehydrogenase(LDH),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) in brains and the contents of malondialdehyde(MDA) and nitric oxide(NO) in CIR model mice were observed.RESULTS:
Compared with the CIR group,crocetin(50,100 mg/kg i.g.for 5 d) decreased the content of water,Evans blue,MDA and NO in mice brain tissue,and increased LDH、SOD and GSH-Px activity in brains of CIR mice,with statistical significance.CONCLUSION:
Crocetin has protective effects on cerebral ischemia-reperfusion injury in mice,the mechanism may be related to its anti-oxidative activity and inhibition of NO overproduction.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
1999
Document type:
Article