Effects of chrysophanol on memory impairment and LTP in AD rats induced by A?_(25-35) / 中国药理学通报

ABSTRACT

Aim To observe the effects of chrysophanol on memory impairment and synaptic transmission in the dentate gyrus of hippocampus in AD rats induced by ?-amyloid peptide(A?25-35).Methods AD rat model was established by injection of A?25-35 into cerebral ventricles with cerebral three-dimensional positioning.Chrysophanol of different doses(0.350,0.070 and 0.014 mg?kg-1 ip) were administered continuously.Through the methods of morris water maze test and electrophysiological test,the effects of chrysophanol on memory impairment and long-term potentiation(LTP) induced by high-frequency stimulation(HFS) in AD rats were observed.Results Chrysophanol(0.350,0.070,0.014 mg?kg-1,ip) does-dependently shortened the time of seeking platform and significantly improved the LTP induced by HFS in the DG of hippocampus in AD rats.Conclusion Chrysophanol can improve memory impairment and possess enhancement property on the LTP induced by HFS in AD rats induced by A?25-35.