Pharmacological Action of Shenfukang on Rat Model with Nephritis Induced by Cationized Bovine Serum Albumin / 广州中医药大学学报

ABSTRACT

Shenfukang is an effective formula for glomerulonephritis applied in the first affiliated hospital of Guangzhou University of TCM. It is composed of Radix Folium seu Flos Tripterygii wilfordii, Radix Astragali seu Hedysari, Radix Notoginseng, Herba Leonuri, etc.. Glomerulonephritis rat model was induced by cationized bovine serum albumin (C-BSA) according to Border's method and was used to observe the pharmacological action of Shenfukang. The results showed that Shenfukang can eliminate urine protein, increase the levels of serum protein, albumin (A), globulin (G) and A/G ratio, and decrease the contents of serum cholesterol, creatinine and urea nitrogen. It can also counteract the increase of plasma TXB 2 and the decrease of plasma 6-keto-PGF 1? . LD 50 of Shenfukang for mice is 174.34?36.74?g/kg which is much larger than that of Tripterygium wilfordii (29.73?6.46?g/kg for female mice and 101.74?10.93?g/kg for male mice). It is indicated that Shenfukang exerts a protective effect on renal function and reduces toxicity of Tripterygium wilfordii.