Analysis of resistance to second-line drugs in 174 strains of multidrug resistance mycobacterium tuberculosis / 国际检验医学杂志

ABSTRACT

Objective To analyze the resistance to second-line anti-TB drugs in multi-drug resistant mycobacterium tuberculosis to provide reference for the treatment of multi drug resistant tuberculosis.Methods The data of the sputum culture and the drug sensitivity results from May 2011 to May 2013 were analyzed by the retrospective analysis method.The drug resistant rates of multi-drug resistant mycobacterium tuberculosis to 5 kinds of second-line anti-TB drug were compared.Results The resistance rates of multi-drug resistant mycobacterium tuberculosis in the initial treatment to the second-line anti-TB drugs of levofloxacin, para aminosalicylic acid,protionamide,amikacin and capreomycin in sequence from high to low were 17.7%,14.5%,12.9%,8.1%and 3.2% respectively.The resistance rate to two kinds of anti-TB drugs was 4.8%,which to 3 kinds and more than 3 kinds of an-ti-TB drugs were all 3.2%.The sequence of the drug resistance rates in the retreatment was same as to that in the initial treatment. But the resistance rates were different,which to levofloxacin,para aminosalicylic acid,protionamide,amikacin and capreomycin were 50.0%,33.9%,25.9%,21 .4% and 16.1 % respectively.The resistance rate to 2 kinds of anti-TB drugs was 16.1%,which to 3 kinds and more than 3 kinds of anti-TB drugs were 13.4% and 12.5% respectively.There were statistical significant differences in the drug resistance rate between the retreatment and the initial treatment in all various circumstances(all P <0.05).Conclusion The drug resistance rate of multi-drug resistant mycobacterium tuberculosis in our hospital is lower than the average level in our country and the drug resistance rate in the retreatment is higher than that in the initial treatment.