Effect of Plastrum Testudinis on Three Subtypes of NOS Expression in Rats with Focal Cerebral Ischemia

Dongfeng CHEN; Shaohui DU; Yiwei LI; Jin ZHANG; Hui LI

Effect of Plastrum Testudinis on Three Subtypes of NOS Expression in Rats with Focal Cerebral Ischemia / 中药新药与临床药理

Dongfeng CHEN; Shaohui DU; Yiwei LI; Jin ZHANG; Hui LI.

Traditional Chinese Drug Research & Clinical Pharmacology ; (6)2000.

Article in Chinese | WPRIM (Western Pacific) | ID: wpr-570724

Responsible library: WPRO

ABSTRACT

ABSTRACT

Objective:

To explore the effect of Plastrum Testudinis on the three subtypes of NOS (nNOS,iNOS,eNOS) expression in rats with focal cerebral ischemia.

Methods:

Rat model of focal cerebral ischemia was set up by inserting nylon thread into the internal carotid artery . The expressions of nNOS, iNOS and eNOS was detected by immunohistochemical method to observe the effects of Plastrum Testudinis.

Results:

Expressions of nNOS and iNOS in cerebral cortex and caudate-putamen of Plastrum Testudinis treatment group were significantly lower than those of model control group (P

Carapax et plastrum testudinis/pharmacology; @Focal cerebral ischemia/TCD therapy; @nNOS/analysis; @iNOS/analysis; @eNOS/analysis; Disease models, animal

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 2000 Document type: Article

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Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 2000 Document type: Article