Efficacy and safety of metoclopramide and ondansetron in preventing nausea and vomiting induced by chemotherapy or operation: a meta-analysis / 中华消化杂志

ABSTRACT

Objective To evaluate the efficacy and safety of metoclopramide and ondansetron in preventing nausea and vomiting induced by chemotherapy or operation. Methods Medline database from 1966 to 2002 and CBMdisc database from 1978 to 2002 were used for sources. The studies were set up according to the inclusion/exclusion criteria. The information about trial design, characters of participants and results from the data were independently extracted, and the studies were blindly evaluated by two authors. The studies were tested for heterogeneity of the odds ratio (OR).Results A total of 33 studies were collected (score range of 65-95), of which 19 were high quality for its score(≥85).Ondansetron was more effective than metoclopramide on preventing nausea and vomiting in short term (within one day and three days), and they have similar effects on preventing nausea and vomiting in the long term (more than three days). However, the pooled OR of effective rate of metoclopramide and ondansetron were 0.13-0.70 (P