Clinical and pathological analysis of bladder sarcomatoid carcinomas / 重庆医科大学学报

ABSTRACT

Objective:To improve the realization, diagnosis and treatment level of bladder sarcomatoid carcinomas.Methods:The tissue resource,the pathological and immunohistochemistry characters,the diagnosis and prognosis of sarcomatoid carcinomas were analyzed and differential diagnosis from bladder carcionomas was established by summarizing the clinical,pathological data and existing related articles.Results:2 cases in this group were diagnosed as transitional cell carcinoma of bladder.The patients underwent partial cystectomy.The pathological study indicated the tumor composed of many fusiform cells,and the transitional cell carcinoma,squamous carcinoma,adenocarcinoma and small cell nest were all included.There was transitional area between fusiform cells and tumor cells.Immunohistochemical examination showed that sarcomatous compoments were stained for epithelial markers.The patiems recovered well without radiotherapy and chemotherapy.However,these 2 patients died of tumor recurrence and metastasis 10 months later.Conclusion:Like general bladder tumor,hematuria is the chief symptom of sarcomatoid carcinomas.B-ultrasonography,CT and MRI can help turnor staging.Final diagnosis depends on pathology and immunohistochemistry.Differential diagnosis between sarcomatoid carcinoma and carcinosaroma should be made.The tumor will undergo blood metastasis in early stage.Prognosis of this kind is poor.The key to improve the prognosis is its early detection.