Pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in rabbit / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
in Zh
| WPRIM
| ID: wpr-574422
Responsible library:
WPRO
ABSTRACT
AIM: To study the pharmacokinetics of ligustilide in the volatile oil from Angelica Sinensis(Oliv.) Diels in the rabbit. METHODS: HPLC method for ligustilide determination in the blood was developed.The HPLC system consisted of C_(18) column using MeOH-H_2O(65∶35,v/v) as mobile phase at a flow rate of 1.0 mL/min and UV detection at 236 nm. RESULTS: Linear calibration curves were obtained over the concentration range of 0.40 ?g?mL~(-1)~10.00 ?g?mL~(-1) for ligustilide.The minimum limit detection was 0.40 ?g?mL~(-1).The recovery of ligusitilide in blood was 90.90% with RSD 2.74%. CONCLUSION: After oral administration of volatile oil,intracorporal process of ligustilide in rabbit accords with 2-compartment model with 1 st order absorption,(2.6638) h and 108.88 h are obtained as t_(1/2?) and t_(1/2?) respectively.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Document type:
Article