Prospective investigation of postoperative lower extremity deep venous thrombosis in gynecological procedures / 中华妇产科杂志

ABSTRACT

Objective To investigate the morbidity, relevant factors and diagnostic methods of lower extremity deep venous thrombosis (LEDVT) after gynecological pelvic surgeries. Methods A prospective study was carried out investigating the morbidity, characteristics, risk factors, the coagulation function changes and diagnostic methods of LEDVT post-gynecological pelvic operations in 141 cases. Platelet, prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin time, D-dimer, antithrombin-Ⅲ, tissue plasminogen activator, plasminogen activator inhibitor were measured within 1 week before surgeries,48 hours and 5-7 days post-surgeries respectively. Color Doppler flow imaging was performed simultaneously. Results (1)Twenty-two cases were found with LEDVT, the morbidity of LEDVT after gynecological procedures was 15.6%. It occurred 2-7 days post operation.(2)The risk factors were bedfasting, coagulant prescription post-operation, cardiovascular disease, ageing, pelvic lymphadenectomy, general anesthesia, and malignancy. Multivariate regression showed only age and coagulant prescription post-operation were independent factors. (3)The level of D-dimer was (0.9?0.6) mg/L in LEDVT group, significantly higher than that of non-LEDVT group[(0.5?0.4) mg/L, P