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Experimental Study on the Anti-arrhythmic Effect and the Safety of Plumula nelumbinis Microcapsules / 中药新药与临床药理
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-575571
Responsible library: WPRO
ABSTRACT
Objective To study the safety of Plumula nelumbinis microcapsules and its anti-arrhythmic effect.Methods Acute toxicity test in mice,arrhythmia mice models induced by chloroform and arrhythmia rats models induced by barium chloride(BaCl2)were adopted.Results The maximum tolerance dose for mice was 16.0 g/kg body weight.The microcapsule decreased the incidence of chloroform-induced ventricular fibrillation in mice significantly(P 0.05,compared with the blank control group).Conclusion The preliminary results show that Plumula nelumbinis microcapsule is safe,and exerts anti-arrhythmic effect against experimental arrhythmia.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 1993 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Traditional Chinese Drug Research & Clinical Pharmacology Year: 1993 Document type: Article
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