Dissolution of Longdan Xiegan Pill by HPLC / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-576018
Responsible library:
WPRO
ABSTRACT
AIM:
To determine the dissolution of Longdan Xiegan Pills(Radix et Rhizoma Gentianae,Radix Scutellariae,Fructus Gardeniae,etc.) on the basis of markers such as gentiopicroside,baicalin and geniposide.METHODS:
According to Appendix ⅩCⅢ of Chinese Pharmacopoeia 2005 edition VolⅡ,dissolution medium was 100 mL 0.5% SDS aqueous solution and rotating speed was 100 r/min.The dissolution solution of pill was taken and analyzed by HPLC method.A column of Kromasil C_(18)(4.6 mm?250 mm,5 ?m) was used.The mobile phase composed of A acetonitrile,B 1% glacial acetic acid aqueous solution,gradient eluation.The flow rate was 1.0 mL/min with the detection wavelength at 254 nm.RESULTS:
The average dissolution of three batches of gentiopicroside,baicalin and geniposide exceeded the marker amount by factor of 0.75 time in 4 h.CONCLUSION:
A reliable and qualitative method is established with good reproducibility for determination of dissolution of Longdan Xiegan Pills.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Qualitative research
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
1992
Document type:
Article