Effects of Ketangte 2 on Experimental Diabetes in Mice / 中药新药与临床药理

ABSTRACT

Objective To observe the effects of Ketangte 2 on experimental diabetes in mice.Methods Adrenalin and streptozocin(STZ) were used to induce hyperglycemia mice model and diabetic mice model respectively.The mice were divided into five groups randomly:model group,glibenclamide control group,high-,middium-,low-dosage Ketangte 2 groups.The administration lasted consecutive 15 days.The blank control group and model group were treated with the same volume of saline.After treatment,the levels of blood sugar were measured in hyperglycemia mice induced by adrenalin,and the fasting blood-glucose,2-hour blood-glucose,insulin levels in diabetic mice induced by STZ were determined.Meanwhile the histopathological changes of pancreas were observed under light microscope.Results For STZ-induced diabetic mice,the hypoglycemic effect of Ketangte 2 was obvious(P