Effect of Danchi Capsule on the Changes of Cytokine and Cell Activity of Cell Supernatant of Eutopic Endometrium in Patients with Endometriosis / 中国中医药信息杂志

ABSTRACT

Objective To reaserch the effect of Danchi capsule on the changes of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-? (TNF-?) and solution intercellular adhesion molecule-1 (sICAM-1) of cell supernatant of eutopic endometrium in patients with edndometriosis. Methods Cells were divied into five groups:Danchi large, medium, small dosage group, blank group and dannazol group in control, detected by ELISA method and MTT method. To observe the levels of MCP-1, TNF-?and sICAM-1 of eutopic endometrial cells and cell activity. Results The group of DanChi large dosage decreased significantly the level of TNF-?, the group of Danchi large and medium dosage decreased the level of MCP-1 significantly. Conclusion Danchi capsule may descend and inhibite the production and activity of these cytokines which involved in three steps: adhesion and implantation-angiogenesis-progression and infiltration, then inhibit adhesion and implantation of endometrial cells.