Effect of Angong Niuhuang Pill and the heavy metal constituents on EcoG of brain damage in rats caused by LPS / 中成药

ABSTRACT

AIM:To evaluate the actions of cinnabaris and realgar in arousing brain and opening the orifices of Angong Niuhuang Pill,and to provide experimental basis for the rationality of Angong Niuhuang Pill buildup. METHODS: The brain damage model was made by LPS injection through caudal vein.With quantitative electroencephalogram of medicine methods,effects of Angong Niuhuang Pill,Angong Niuhuang Pill without cinnabaris and realgar,cinnabaris,realgar on the power and relative power of delta and beta waves of electrocorticogram(ECoG) were observed in the brain damage rats caused by LPS. RESULTS: LPS could increase the power and the relative power of the delta waves(0.5-3 Hz),and reduce the power and the relative power of the beta waves(14-30 Hz).All medicines could reduce the power and the relative power of the delta;Angong Niuhuang Pill,cinnabaris and realgar,realgar could increase the power and the relative power of the beta,cinnabaris could increase the relative power of the beta(14-30 Hz),and Angong Niuhuang Pill without cinnabaris and realgar could not. CONCLUSION: Angong Niuhuang Pill has obvious activation on ECoG,and same as cinnabaris and realgar.The results of the present work allow us to put forward the hypothesis that cinnabaris and realgar are most likely one of the important material basis in arousing brain and opening the orifices of Angong Niuhuang Pill.