Correlation between expression of focal adhesion kinase and vascular endothelial growth factor in squamous cell carcinoma of larynx / 重庆医科大学学报

ABSTRACT

Objective:To detect the expression of focal adhesion kinase(FAK) and vascular endothelial growth factor(VEGF)in human laryngeal squamous cell carcinoma to study their correlation in invasion and metastasis.Methods:Immunohistochemical S-P method was used to detect the expression of FAK and VEGF in 42 case of human laryngeal squamous cell carcinoma and 40 cases of polyp of vocal cords.All the samples were stained by HE method to confirm their pathologic characteristics.Positive rates of FAK and VEGF were evaluated by microscopy.Results:The positive rates of FAK,VEGF were 79% and 71%,respectively in human laryngeal squamous cell carcinoma.While in polyp of vocal cords,13% and 18%,respectively.The difference was significant(P