Effects of Single Leaf Asarum on Pulmonary Ventilation Function in Rats with Experimental Syndrome of Cold Fluid Shooting Lung / 中国中医药信息杂志

ABSTRACT

Objective To study the effects of single leaf Asarum on pulmonary ventilation in experimental rats with syndrome of cold fluid shooting lung. Methods Wistar rats were randomly divided into three groups including singe leaf Asarum group [fed with water extracts of singe leaf Asarum 1 mL/(kg?d)], singe leaf Asarumi Miq group [fed with water extracts of singe leaf Asarumi Miq 1 mL/(kg?d)] and normal saline group [fed with 0.9% normal saline 1 mL/(kg?d)]. After fed continually for 6 days, whole lung of rats were washed with normal saline [7 ℃, 2.5 mL/(kg?d)] and then were perfused for 30 seconds. This treatment was repeated 5 times every 5 minutes to make the model of cold fluid shooting lung. The fluid of perfusion was collected and detected. The changes of TXB2, ET, protein and phospholipids of the fluid were measured before and after lavage. Results TXB2, ET and protein in the perfusing fluid ascended obviously, while phospholipids were low in normal saline group. TXB2 and ET in singe leaf Asarum group and single leaf Asarumi Miq group were less than that in normal saline group (P