FOXC1 expression in cervical cancer and endometrial cancer / 重庆医科大学学报

ABSTRACT

Objective:To investingate potential correlations between FOXC1 expression and clinicopathologic features of endometrial cancer and cervical cancer.Methods:FOXC1 protein expression in 54 cases of cervical cancer and 23 of endometrial cancer were investigated with immunohistochemistry.Results:FOXC1 protein expression was observed in cancer tissues,including both endometrial and cervical cancer.Positive FOXC1 expression was revealed in 20(87.0%)of endometrial cancer and 29(53.7%)of cervical cancer.Significant correlation in retrospective study was observed between FOXC1 protein expression and histological grades(P0.05).Conclusion:FOXC1 may play a role in tumorigenesis of cervical cancer.FOXC1 may have no correlation with tumorigenesis of endometrial cancer.