Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report
Journal of Korean Medical Science
; : 824-828, 2011.
Article
in En
| WPRIM
| ID: wpr-58116
Responsible library:
WPRO
ABSTRACT
Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Paraproteinemias
/
Vincristine
/
Bone Marrow
/
Prednisolone
/
B-Lymphocytes
/
Doxorubicin
/
Waldenstrom Macroglobulinemia
/
CD5 Antigens
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Cryoglobulinemia
/
Cyclophosphamide
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2011
Document type:
Article