Efficacy of Levofloxacin and Rifaximin based Quadruple Therapy in Helicobacter pylori Associated Gastroduodenal Disease: A Double-Blind, Randomized Controlled Trial
Journal of Korean Medical Science
; : 785-790, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-58122
Responsible library:
WPRO
ABSTRACT
The aim of this study was to evaluate the efficacy of levofloxacin and rifaximin based quadruple regimen as first-line treatment for Helicobacter pylori infection. A prospectively randomized, double-blinded, parallel group, comparative study was performed. Three hundred consecutive H. pylori positive patients were randomized to receive omeprazole, amoxicillin, clarithromycin (OAC); omeprazole, amoxicillin, levofloxacin (OAL); and omeprazole, amoxicillin, levofloxacin, rifaximin (OAL-R). The eradication rates in the intention to treat (ITT) and per protocol (PP) analyses were OAC, 77.8% and 85.6%; OAL, 65.3% and 73.6%; and OAL-R, 74.5% and 80.2%. The eradication rate achieved with OAC was higher than with OAL on the ITT (P = 0.05) and PP analysis (P = 0.04). OAL-R regimen was not inferior to OAC. The frequency of moderate to severe adverse effects was significantly higher in OAC treatment group. Especially, diarrhea was most common complaint, and there was a significantly low rate of moderate to severe diarrhea with the rifaximin containing regimen. In conclusion, the levofloxacin and rifaximin based regimen comes up to the standard triple therapy, but has a limited efficacy in a Korean cohort. The rifaximin containing regimen has a very high safety profile for H. pylori eradication therapy.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
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Diarrhea
/
Neglected Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
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Rifamycins
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Omeprazole
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Ofloxacin
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Double-Blind Method
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Prospective Studies
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Helicobacter pylori
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Helicobacter Infections
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Clarithromycin
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Diarrhea
Type of study:
Controlled clinical trial
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Practice guideline
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Observational study
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Risk factors
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Document type:
Article