Changes of circulating ET, A Ⅱ, CGRP after PTCA in the patients associated with acute coronary events / 中国介入心脏病学杂志

ABSTRACT

Percutaneous transluminal coronary angioplasty (PTCA) was done successfully in 33 patients,6 of them were associated with 8 acute coronary events. Radioimmunoassay was used for the determination of plasmaET,AII and CGRP levels. The samples were drawn successively from femoral artery just before PTCA and 0min, 15min,1h,3h,24h after the final balloon inflation. The results showed that the levels of plasma AII were higher in the complication group than those of noncomplication group before PTCA and 0min, 24h after PTCA. The differences in plasma ET levels before and after PTCA between the complication group and the non-complication group were not significant. The level of plasma CGRP was decreased at 15min and returned to basal level at 1h after PTCA in the complication group.In the patients without complication,there were no significant differences in their plasma CGRP levels before and after PTCA. All + ET/CGRP in the complication group raised more rapidly,recovered later and the peak appeared earlier than that of non-complication group. For a better understanding pathophysiologic meaning of the above changes,further studies are needed.