In vitro Biological Characteristic Changes and in vivo Tumorigenicity of mlL-4 Gene Modified G422 Cells by Adenovirus-Mediated Gene Transfer / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy
; (6)1996.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-581736
Responsible library:
WPRO
ABSTRACT
Murine interleukin-4 gene(mIL-4) was transfected into mice glioblastoma cell line G422 by recombinant adenovirus vector. We detected mRNA transcription of target gene in gene modified tumor cells(G422-mIL4). High level of mouse IL-4 could be detected in the culture supernatant of G422-mIL4. When inoculated subcuatneously, the tumor growth of G422-mIL4 was significantly inhibited as compared to wild type G422 and LacZ gene modified G422( G422-LacZ) . The period of survival of mice inoculated with G422-mlL4 was significantly prolongated(p
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Cancer Biotherapy
Year:
1996
Document type:
Article