Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats / 吉林大学学报(医学版)

ABSTRACT

Objective To study the ameliorative effects of pseudoginsenoside GQ (PGQ) on electrocardiogram changes in rats with acute myocardial ischemia induced by isoproterenol (ISO). Methods 50 Wistar rats were divided into five groups (n=10) randomly. Group I i. v. 0.9% sodium chloride water liquor; Group II i. v. verapamil hydrochloride of 0. 2 mg ? kg-1 ; Group III i. v. 3. 0 mg ? kg-1 of PGQ; Group IV i. v. 6. 0 mg ? kg-1 of PGQ; Group V i. v. 12. 0 mg ? kg-1 of PGQ. Myocardial ischemia was induced by intravenous injection of ISO (2.0 mg ? kg-1). ST-segment changes in the lead II , precordial in lead V1 and precordial in lead V2 were examined. Results In lead II , lead precordial V 1 and lead precordial V 2 , ST-segment elevation of three PGQ groups were not obvious at every time point, the extents of ST-segment elevation were lower than those in sodium chloride water liquor group (P