Homeobox genes CDX1 and CDX2 reduced malignancy of esophageal adenocarcinoma cells / 基础医学与临床
Basic & Clinical Medicine
; (12)2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-588103
Responsible library:
WPRO
ABSTRACT
Objective To study the effect of homeobox genes CDX1 and CDX2 on the phenotype of esophageal adenocarcinoma cells.Methods Esophageal adenocarcinoma cell line SEG-1 was transfected with CDX1 or CDX2 cDNA.The morphology,growth rate,division index and tumorigenicity were analyzed.Results The expression of CDX1 or CDX2 leaded to occurring adeniform-like manifestation.The growth rate,division index and tumorigenicity were reduced,especially by CDX2.Conclusion CDX1 and CDX2 all could increase differentiation of esophageal adenocarcinoma cells and reduction of its malignancy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2006
Document type:
Article