Differentiation of human umbilical cord blood cells into neural cells for treatment of rats with hypoxic-ischemic brain injury via transplantation / 中国组织工程研究

ABSTRACT

OBJECTIVE: To comprehensively analyze the feasibility of neural differentiation from human umbilical cord blood cells and the transplantation in treating rats with hypoxic-ischemic brain injury. DATA SOURCES: A computer-based online search of Pubmed was undertaken for articles about neural differentiation from human umbilical cord blood cells in the treatment of rats with hypoxic-ischemic brain injury via transplantation published in English between January 2000 and December 2005 by using the keywords of "mesenchymal stem cells, umbilical cord blood, transplantation". Meanwhile, we searched the Wanfang database for related Chinese literature published between January 2002 and December 2005 with the same key words in Chinese. STUDY SELECTION: The articles about neural differentiation from human umbilical cord blood cells and transplantation in treating rats with hypoxic-ischemic brain injury were arranged to select those with strong points. As to those in the same field, the articles published recently or in authorized journals were included. DATA EXTRACTION: Totally 37 articles were collected, of which 31 ones were accorded the criteria and 6 were excluded. DATA SYNTHESIS: Many studies showed that mesenchymal stem cells with strong plasticity could be isolated from umbilical cord blood. Also, mesenchymal stem cells from umbilical cord blood have many merits: ①It is primitive with inferior antigenicity and few primary cells with toxicity, so the incidence rate of graft versus host disease is low, and the adverse effect is slighter; moreover, the blood has strong differentiated ability, can express stably exogenous target gene in vivo and in vitro. ②With widespread source, large quantity, easy to collect, prepare and store, not involving in the problem of society, ethics and law and so on. Therefore, mesenchymal stem cells can be used as a new source to treat central nervous system disease. CONCLUSION: Though mesenchymal stem cells have wide application prospect, the research on the transplantation in treating nervous system disease is emerging and vacant in many areas, so we need to do further study to provide a new channel for treating central nervous system disease.