Inhibition of caspase-12 expression by NGF in rabbit cerebral ischemia/reperfusion injury / 基础医学与临床

ABSTRACT

Objective To observe the effect of NGF on the caspase-12 in cerebral ischemia/reperfusion. MethodsTwenty-six healthy male white rabbits were randomly divided into sham, ischemia/reperfusion and NGF group. The tissues were sampled to detect the expression of caspase-12, caspase-3 by immunohistochemistry, and to detect the cerebral apoptosis by flow cytometry and TUNEL staining methods.Results Compared with sham group, the expression of caspase-12 and caspase-3 in I/R group was higher (P