Effects of tetrandrine on proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE / 医学研究生学报
Journal of Medical Postgraduates
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-588888
Responsible library:
WPRO
ABSTRACT
Objective:To investigate the effects of tetrandrine(Tet) on proliferaton and apoptosis of nasopharyngeal carcinoma cell line CNE.Methods:CNE cells were divided into groups and treated by Tet at different concentrations.Inhibitory effects of tetrandrine were determined by MTT assay.The morphologic changes of CNE cells were observed by transmission electron microscope.DNA fragmentations were determined by gel electrophoresis assay.Cell apoptosis was investigated by flow cytometer.The expressions of apoptosis-related genes were detected by retrotranscriptase polymerase chain reaction(RT-PCR).Results:Tetrandrine possessed inhibitory effect on CNE cell proliferation in a concentration-dependent manner(P
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Medical Postgraduates
Year:
2003
Document type:
Article