Fungal Infection and Drug Resistance of Fungal Strains Isolated from Blood Culture / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the current status about fungal infections in hospital and to provide the evidence to clinical treatment by identification,and susceptibility test for 62 strains of fungal infection in target population.METHODS The positive sample of blood culture was detected by Bio-Merieux Bact/Alert 3D fully automated microbial detect system,and the fungus identified by Bio-Merieux API 20C Aux yeast system,VITEK identification system,or YBC identification card.The susceptibility test perform by ATB Fungus 2 INT tip.The fungal strains were cultured with Sabouraud medium.RESULTS Among the 62 fungal strains,61 were Candida which accounted for 88.7%,from them C.albicans was predominan,accounted for 35.5%.Susceptibility rate to fluconazole,amphotericin B,itraconazole and flucytosine was 91.0%,100.0%,91.0%,and 100.0%.The distribution of fungi was higher in ICU accounted for 50.0% than in other wards.CONCLUSIONS The rate of the Candida especially C.albicans infection is increasing in Beijing Hospital.The result of susceptibility test showed that the fungi are good susceptibe to antifungal drugs.Highly resistant strain is rare,therefore,the clinics should choose the appropriate antifungal agents and minimize the incidents of resistance of fungal infections according to the culture and in vitro susceptibility of fungus.