Association of LCT-13910 C/T Polymorphism and Colorectal Cancer
Annals of Coloproctology
; : 169-172, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-59260
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The activity of epithelial lactase (LCT) is associated with a polymorphism 13910 bp upstream in the lactase encoding gene. Because the association between the LCT-13910 polymorphism and the risk for colorectal cancer is not clear, we investigated the role of the LCT-13910 polymorphism as a potential risk factor for colorectal cancer and colorectal polyps in the Turkish population.METHODS:
One hundred sixty-six subjects (74 with polyps, 44 with colorectal cancer, 48 controls), who had undergone a total colonoscopy between January 2012 and November 2012 in our endoscopy unit were genotyped for the LCT-13910 polymorphism by using the polymerase chain reaction and minisequencing.RESULTS:
The CC genotype in the lactose gene 13910 locus, which is accepted as the genetic indicator of lactase deficiency, was determined as 83.7%. The CC genotype rate was determined as 89.1% in patients who had a history of lactose intolerance and 81.5% in those without a history of lactose intolerance (P = 0.236). No difference was detected between the patients who had colorectal polyp(s) and/or cancer and the controls with regard to the LCT-13910 polymorphism. No differences were determined between groups when they were compared with regard to the C or the T allele.CONCLUSION:
No differences were detected between the patients who had colorectal polyp(s) and/or cancer and those with normal colonoscopy findings with regard to lactase gene polymorphisms. No differences were determined between the groups when they were compared with regard to the C or the T allele.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polyps
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Polymerase Chain Reaction
/
Risk Factors
/
Colonoscopy
/
Lactase
/
Endoscopy
/
Alleles
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Coloproctology
Year:
2017
Document type:
Article